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Publications Based on, and Supported by, Conte Center P50-MH103222 (2014 – 2018)

Nugent KL, Chiappelli J, Rowland LM, Daughters SB and Hong LE. Distress intolerance and clinical functioning in persons with schizophrenia. Psychiatry Res., 220: 31-6 (2014)

Wonodi I, McMahon RP, Krishna N, Mitchell BD, Liu J, Glassman M, Hong LE and Gold JM. Influence of kynurenine 3-monooxygenase (KMO) gene polymorphism on cognitive function in schizophrenia. Schizophr. Res., 160: 80-7 (2014)

Pershing ML, Bortz DM, Pocivavsek A, Fredericks PJ, Jørgensen CV, Vunck SA, Leuner B, Schwarcz R and Bruno JP. Elevated levels of kynurenic acid during gestation produce neurochemical, morphological, and cognitive deficits in adulthood: implications for schizophrenia. Neuropharmacology, 90: 33-41 (2015)

Blanco-Ayala T, Lugo-Huitrón R, Carmona-Aparicio L, Ramírez Ortega D, González Esquivel D, Pedraza-Chaverrí J, Pérez-de la Cruz G, Ríos C, Schwarcz R and Pérez-de la Cruz V. Alternative kynurenic acid synthesis routes studied in the rat cerebellum. Front. Cell. Neurosci., 9, Article 178 (2015)

Zanos P, Piantadosi SC, Wu HQ, Pribut HJ, Dell MJ, Can A, Snodgrass HR, Zarate Jr. CA, Schwarcz R and Gould TD. The prodrug 4-chlorokynurenine causes ketamine-like antidepressant, but not side effects, by NMDA/glycineB-site inhibition. J. Pharmacol. Exp. Therap., 355: 76-85 (2015)

Pocivavsek A, Notarangelo FM, Wu HQ, Bruno JP and Schwarcz R. Astrocytes as pharmacological targets in the treatment of schizophrenia: focus on kynurenic acid. In: Modeling the Psychopathological Dimensions of Schizophrenia. Handbooks of Behavioral Neuroscience, volume 23 (M. Pletnikov and J. Waddington, eds.), 423-43 (2015)

Sullivan EM, Timi P, Hong LE and O'Donnell P. Reverse translation of clinical electrophysiological biomarkers inbehaving rodents under acute and chronic NMDA receptor antagonism. Neuropsychopharmacology, 40: 719-27 (2015)

Chiappelli J, Hong LE, Wijtenburg A, Du M, Gaston F, Kochunov P and Rowland LM. Alterations in frontal white matter neurochemistry and microstructure in schizophrenia: implication of neuroinflammation. Transl. Psychiatry, 5: e548 (2015)

Nugent KL, Chiappelli J, Rowland LM and Hong LE. Cumulative stress pathophysiology in schizophrenia as indexed by allostatic load. Psychoneuroendocrinology, 60: 120-9 (2015)

Zanos P, Bhat S, Terrillion CE, Smith RJ, Tonelli LH and Gould TD. Sex-dependent modulation of age-related cognitive decline by the L-type calcium channel gene Cacna1c (Cav 1.2). Eur. J Neurosci., 42: 2499-507 (2015)

Nugent KL, Chiappelli J, Rowland LM and Hong LE. Cumulative stress pathophysiology in schizophrenia as indexed by allostatic load. Psychoneuroendocrinology, 60: 120-9 (2015)

Fedota J, Sutherland MT, Salmeron BJ, Ross TJ, Hong LE and Stein EA. Reward anticipation is differentially modulated by varenicline and nicotine in smokers. Neuropsychopharmacology, 40: 2038-46 (2015)

Chiappelli J, Rowland LM, Wijtenburg A, Muellerklein F, Tagamets M, McMahon R, Gaston F, Kochunov P and Hong LE. Evaluation of myo-inositol as a potential biomarker for depression in schizophrenia. Neuropsychopharmacology, 40: 2157-64 (2015)

Nugent KL, Chiappelli J, Sampath H, Rowland LM, Thangavelu K, Davis B, Du X, Muellerklein F, Daughters S, Kochunov P and Hong LE. Prolonged cortisol reactivity to stress and white matter in schizophrenia. Psychosom. Med., 77: 733-42 (2015)

Herskovits EH, Hong LE, Kochunov P, Sampath H and Chen R. Edge-centered DTI connectivity cnalysis: application to schizophrenia. Neuroinformatics, 13: 501-9 (2015)

Wright SN, Hong LE, Winkler AM, Chiappelli J, Nugent K, Muellerklein F, Du X, Rowland LM, Wang DJ and Kochunov P. Perfusion shift from white to gray matter may account for processing speed deficits in schizophrenia. Hum. Brain Mapp., 36: 3793-804 (2015)

Goeden N, Velasquez J, Arnold KA, Chan Y, Lund BT, Anderson GM, and Bonnin A. Maternal inflammation disrupts fetal neurodevelopment via increased placental output of serotonin to the fetal brain. J. Neurosci., 36: 6041-9 (2016)

Clark SM, Soroka JA, Song C, Li X and Tonelli LH. CD4(+) T cells confer anxiolytic and antidepressant-like effects, but enhance fear memory processes in Rag2(-/-) mice. Stress, 19: 303-11 (2016)

Song C, Nicholson JD, Clark SM, Li X, Keegan AD and Tonelli LH. Expansion of brain T cells in homeostatic conditions in lymphopenic Rag2(-/-) mice. Brain Behav. Immun., 57: 161-72 (2016)

Wang Q, Chen R, JaJa J, Jin Y, Hong LE and Herskovits EH. Connectivity-based brain parcellation: a connectivity-based atlas for schizophrenia research. Neuroinformatics, 14: 83-97 (2016)

Chiappelli J, Shi Q, Kodi P, Savransky A, Kochunov P, Rowland LM, Nugent KL and Hong LE.  Disrupted glucocorticoid - immune interactions during stress response in schizophrenia. Psychoneuroendocrinology, 63: 86-93 (2016)

Kochunov P, Thompson PM, Winkler A, Morrissey M, Fu M, Coyle TR, Du X, Muellerklein F, Savransky A, Gaudiot C, Sampath H, Eskandar G, Jahanshad N, Patel B, Rowland L, Nichols TE, O'Connell JR, Shuldiner AR, Mitchell BD and Hong LE. The common genetic influence over processing speed and white matter microstructure: evidence from the Old Order Amish and human connectome rojects. Neuroimage, 125: 189-97 (2016)

Kochunov P, Fu M, Nugent K, Wright SN, Du X, Muellerklein F, Morrissey M, Eskandar G, Shukla DK, Jahanshad N, Thompson PM, Patel B, Postolache TT, Strauss KA, Shuldiner AR, Mitchell BD and Hong LE. Heritability of complex white matter diffusion traits assessed in a population isolate. Hum. Brain Mapp., 37: 525-35 (2016)

Rowland LM, Krause BW, Wijtenburg SA, McMahon RP, Chiappelli J, Nugent KL, Nisonger SJ, Korenic SA, Kochunov P and Hong LE. Medial frontal GABA is lower in older schizophrenia: a MEGA-PRESS with macromolecule suppression study. Mol. Psychiatry, 21: 198-204 (2016)

Rowland LM, Summerfelt A, Wijtenburg SA, Du X, Chiappelli JJ, Krishna N, West J, Muellerklein F, Kochunov P and Hong LE. Frontal glutamate and ³ -aminobutyric acid levels and their associations with mismatch negativity and digit sequencing task performance in schizophrenia. JAMA Psychiatry, 73: 166-74 (2016)

Kuehner RM, Kochunov P, Nugent KL, Jurius DE, Savransky A, Gaudiot C, Bruce HA, Gold J, Shuldiner AR, Mitchell BD and Hong LE. Cognitive profiles and heritability estimates in the Old Order Amish. Psychiatr. Genetics, 26: 178-83 (2016)

Chiappelli J, Postolache TT, Kochunov P, Rowland LM, Wijtenburg SA, Shukla DK, Tagamets M, Du X, Savransky A, Lowry CA, Can A, Fuchs D and Hong LE. Tryptophan metabolism and white matter integrity in schizophrenia. Neuropsychopharmacology, 41: 2587-95 (2016)

Wijtenburg SA, Wright SN, Korenic SA, Gaston FE, Ndubuizu N, Chiappelli J, McMahon RP, Chen H, Savransky A, Du X, Wang DJ, Kochunov P, Hong LE and Rowland LM. Altered glutamate and regional cerebral blood flow levels in schizophrenia: A 1H-MRS and pCASL study. Neuropsychopharmacology, 42:  562-71 (2017)

Goeden N, Notarangelo FM, Pocivavsek A, Beggiato S, Bonnin and Schwarcz R. Prenatal dynamics of kynurenine pathway metabolism in mice: focus on kynurenic acid. Dev. Neurosci., 39: 519-28 (2017)

Sathyasaikumar KV, Tararina M, Wu HQ, Neale SA, Weisz F, Salt TE and Schwarcz R. Xanthurenic acid formation from 3-hydroxykynurenine in the mammalian brain: neurochemical characterization and physiological effects. Neuroscience, 367: 85-97 (2017)

Flores-Barrera E, Thomases DR, Cass DK, Bhandari A, Schwarcz R, Bruno JP and Tseng KY. Preferential disruption of prefrontal GABAergic function by nanomolar concentrations of the ±7nACh negative modulator kynurenic acid. J. Neurosci., 37: 7921-9 (2017)

Bortz DM, Wu HQ, Schwarcz R and Bruno JP. Oral administration of a specific kynurenic acid synthesis (KAT II) inhibitor attenuates evoked glutamate release in rat prefrontal cortex. Neuropharmacology, 121: 69-78 (2017)

Erhardt S, Pocivavsek A, Repici M, Liu XC, Imbeault S, Maddison DC, Thomas MAR, Smalley JL, Larsson MK, Muchowski PJ, Giorgini F and Schwarcz R. Adaptive and behavioral changes in kynurenine 3-monooxygenase knockout mice: relevance to psychotic disorders. Biol. Psychiatry, 82: 756-65 (2017)

Notarangelo FM and Pocivavsek A. Elevated kynurenine pathway metabolism during neurodevelopment: Implications for brain and behavior. Neuropharmacology, 112: 275-85 (2017)

Hahn B, Reneski CH, Pocivavsek A and Schwarcz R. Prenatal kynurenine treatment in rats causes schizophrenia-like broad monitoring deficits in adulthood. Psychopharmacology (Berl.), 235: 651-61 (2018)

Puvvada KC, Summerfelt A, Du X, Krishna N, Kochunov P, Rowland LM, Simon JZ and Hong LE. Delta vs gamma auditory steady state synchrony in schizophrenia. Schizophrenia Bulletin, 44: 378-87 (2018)

Pocivavsek A and Rowland LM. Basic neuroscience illuminates causal relationship between sleep and memory: translating to schizophrenia. Schizophrenia Bulletin, 44: 7-14 (2018)

Chiappelli J, Shi Q, Wijtenburg SA, Quiton R, Wisner K, Gaston F, Kodi P, Gaudiot C, Kochunov P, Rowland LM and Hong LE. Glutamatergic response to heat pain stress in schizophrenia. Schizophrenia Bulletin, 44: 886-95 (2018)

Song C, Clark SM, Vaughn CN, Nicholson JD, Murphy KJ, Mou TM, Schwarcz R, Hoffman GE and Tonelli LH. Quantitative analysis of kynurenine aminotransferase II in the adult rat brain reveals high expression in proliferative zones and corpus callosum. Neuroscience, 369: 1-14 (2018)

Ryan MC, Sherman P, Rowland LM, Wijtenburg SA, Acheson A, Fieremans E, Veraart J, Novikov DS, Hong LE, Sladky J, Peralta PD, Kochunov P and McGuire SA. Miniature pig model of human adolescent brain white matter development. J. Neurosci. Method., 296: 99-108 (2018)

Hahn B, Reneski CH, Pocivavsek A and Schwarcz R. Prenatal kynurenine treatment in rats causes schizophrenia-like broad monitoring deficits in adulthood. Psychopharmacology (Berl), 235: 651-61 (2018)

Chiappelli J, Notarangelo FM, Pocivavsek A, Thomas MAR, Rowland LM, Schwarcz R and Hong LE. Influence of plasma cytokines on kynurenine and kynurenic acid in schizophrenia. Neuropsychopharmacology, 43: 1675-80 (2018)

Chiappelli J, Rowland LM, Notarangelo FM, Wijtenburg SA, Thomas MAR, Pocivavsek A, Jones A, Wisner K, Kochunov P, Schwarcz R and Hong LE. Salivary kynurenic acid response to psychological stress: inverse relationship to cortical glutamate in schizophrenia. Neuropsychopharmacology, 43, 1706–11 (2018)

Baratta AM, Buck SA, Buchla AD, Fabian CB, Chen S, Mong JA and Pocivavsek A. Sex differences in hippocampal memory and kynurenic acid formation following acute sleep deprivation in rats. Sci Rep., 8: 6963 (2018)

Tufvesson-Alm M, Schwieler L, Schwarcz R, Goiny M, Erhardt S and Engberg G. Importance of kynurenine 3-monooxygenase for spontaneous firing and pharmacological responses of midbrain dopamine neurons: relevance for schizophrenia. Neuropharmacology, 138: 130-9 (2018)

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Former MPRC Director, Dr. Robert W. Buchanan, provides an overview of the center.

Deanna L. Kelly wins the 2017 Maltz Prize for Innovative & Promising Research from the Brain and Behavior Research Foundation

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